A confluent 2D tissue, where each cell is a Voronoi region around a self-propelled particle. The energy E = Σ [Kₐ(A−A₀)² + Kₚ(P−P₀)²] penalizes deviations in cell area and perimeter from target values.
The dimensionless target shape index p₀ = P₀/√A₀ controls rigidity: below p₀* ≈ 3.813 the tissue is a jammed solid; above, a fluid that flows via T1 rearrangements. Self-propulsion v₀ and rotational noise Dᵣ add active dynamics.
Bi, D., Yang, X., Marchetti, M. C., Manning, M. L. Motility-Driven Glass and Jamming Transitions in Biological Tissues. Phys. Rev. X 6, 021011 (2016).
Sussman, D. M. cellGPU: Massively parallel simulations of dynamic vertex models. Computer Physics Communications 219, 400–406 (2017). [GitHub]