A Synthetic Biomimetic System for Cell Monolayers
To isolate the role of cell shape in tissue fluidization — free from the confounding effects of density changes and variable motility that plague living systems — we designed a monolayer of synthetic cell mimics and systematically tuned their self-propulsion. We discover a shape-driven, density-independent re-entrant jamming transition, and show that cell shape and shape variability are mutually constrained in the confluent limit, following the same universal scaling seen in real epithelia. These experiments establish cleanly that geometric constraints alone can dictate whether a tissue jams or flows. (Collaboration with Prof. Rajesh Ganapathy, JNCASR)
- Arora, P., et al. “A shape-driven reentrant jamming transition in confluent monolayers of synthetic cell-mimics.” Nature Communications 15(1):5645 (2024). DOI